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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment selection for chronic weight management in addition to a reduced-calorie diet and physical activity.

Using two separate drugs to lose weight can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with fat loss and the those who go through it one should err assisting caution and let the FDA do its job and demand some investigation be done in order that the public recognizes the side effects and dangers of the medications before we take them. Keep in mind that drug companies are in business to generate money and that they would say almost anything to keep people on the medications.

Researchers discovered that participants investing in this drug for a year, lost excess weight within a month and have kept the load off throughout the 56 weeks in the study. Contrave can be a combination from the drugs naltrexone and bupropion, which usually reflect a new trend of weight-loss drugs that are made up of several active ingredient, which may make them more efficient and safer.

Combo-pilling is the newest fad or also the newest in the future under scrutiny and therefore it is just more publicly known lately, comb-pilling for losing weight has been around since the eighties. The biggest reason that employing a combination of pills is now popular could be the fact that since right now there are not any long term prescription weight loss supplements that have been licensed by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be authorized by the FDA.

Seizures can be a side effect with Contrave and must not be taken in individuals with seizure disorders. The drug may also raise blood pressure and heartbeat, and really should not be used in those with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise hypertension and heart rate and must stop used in patients with uncontrolled high hypertension, in addition to by anyone with heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients using a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert physicians and patients towards the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stopping smoking.


The most common effects reported with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.